1. SylabUZ
2. Wydział Lekarski i Nauk o Zdrowiu
3. semestr zimowy 2023/2024
4. WLiNZ - oferta ERASMUS / Lekarski - jednolite magisterskie sześcioletnie
5. Elective subject Strategies and types of gene therapy

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Elective subject Strategies and types of gene therapy - opis przedmiotu

Cel przedmiotu

The aim of the course is to gain knowledge about the potential of gene therapy as a therapeutic method. Presentation of the technical aspects of genotherapy, mainly related to gene carriers and the effectiveness of their penetration into the cell, as well as the possibility of expression of the introduced gene.

Wymagania wstępne

Zapisz zmiany

Completed molecular biology course.

Zakres tematyczny

1. An introduction to the subject. Explanation of the term "gene therapy". Assumptions of gene therapy.

2. Molecular cloning. From vector to construct.

3. Therapeutic nucleic acids - types.

4. Types of vectors used in gene therapy.

5. Methods of DNA transfer to the cell.

6. Clinical applications of gene therapy.

7. Ethical problems and safety of gene therapy.

Metody kształcenia

Classes in the form of multimedia presentations and discussions - adapted to face-to-face classes and the use of e-learning platforms.

Efekty uczenia się i metody weryfikacji osiągania efektów uczenia się

Opis efektu	Symbole efektów	Metody weryfikacji	Forma zajęć

Warunki zaliczenia

Pass based on attendance and participation in classes and summary test including single-choice test questions - positive grade from 60% of the points obtained. During the seminar classes, one excused absence is allowed (sick leave). Absences, in each case, must be made up for in the form of a written test or an oral answer covering the scope of the material for the classes, within the time limit agreed with the teacher.

Literatura podstawowa

1. Nóbrega C, Mendonça L, Matos CA. A Handbook of Gene and Cell Therapy. Springer 2020.
2. Giacca M. Gene Therapy, Springer-Verlag Mailand, 2010.
3. Steffin DHM, Hsieh EM, Rouce RH. Gene Therapy: Current Applications and Future Possibilities. Adv Pediatr. 2019; 66:37-54.
4. Kerstin B Kaufmann, Hildegard Büning, Anne Galy, Axel Schambach, Manuel Grez. Gene therapy on the move. EMBO Mol Med. 2013; 5:1642–1661.

Literatura uzupełniająca

Uwagi

Zmodyfikowane przez dr Ewa Bok (ostatnia modyfikacja: 17-05-2023 19:37)