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Biochemistry II (Metabolism) - course description

General information
Course name Biochemistry II (Metabolism)
Course ID 13.6-WB-P-BchII-S21
Faculty Faculty of Exact and Natural Sciences
Field of study WNB - oferta ERASMUS
Education profile -
Level of studies Erasmus programme
Beginning semester winter term 2024/2025
Course information
Semester 2
ECTS credits to win 5
Course type obligatory
Teaching language english
Author of syllabus
  • dr hab. Beata Machnicka, prof. UZ
Classes forms
The class form Hours per semester (full-time) Hours per week (full-time) Hours per semester (part-time) Hours per week (part-time) Form of assignment
Lecture 30 2 - - Credit with grade
Laboratory 30 2 - - Credit with grade

Aim of the course

The main objectives of the course:

- to be able understand and apply the methods used in metabolic studies,

- to gain understanding of the localization, regulation and integration of metabolic pathways and molecular basis of human metabolic diseases.

Prerequisites

Knowledge of physical chemistry, biochemistry and microbiology at the academic level.

Scope

Lecture: Principles of metabolism. Glycolysis and gluconeogenesis are regulated contrary. The citric acid cycle regulation. Regulation of oxidative phosphorylation. The pentosephosphate pathway regulation. Coordinated regulation of glycogen synthesis and breakdown. Fatty acids metabolism regulation. Regulation of biosynthesis of lipids and steroids. Amino acids biosynthesis is under allosteric regulation. Regulation of biosynthesis and degradation of nucleotides. Integration of mammalian metabolism: - key metabolites, - tissue specific metabolism

Laboratory classes - yeast as a model organism in biochemical and genetic research. Study of the regulation of respiratory metabolism in Saccharomyces cerevisiae  yeast mutants. Acryflawin induction of respiratory mutants aci + rho- and aci + rhoo. Growth of aci + mutants on non-fermentable carbon and energy sources.

Teaching methods

Lecture (in a form of multimedia presentation) - Practical method – laboratory classes with the use of Saccharomyces cerevisiae mutants as a model organism and microbiological equipment.

Learning outcomes and methods of theirs verification

Outcome description Outcome symbols Methods of verification The class form

Assignment conditions

The lectures- the final examination test after getting the pass mark credit of the classes. It is conducted in the written form. The laboratory classes: the attendance at classes, the laboratory experiments carried out correctly and the pass mark credit of  tests. Positive marks - 60% of correct answers.

Recommended reading

Stryer; et al. (2015). Biochemistry (8 ed.).

Further reading

Notes


Modified by dr Elżbieta Roland (last modification: 06-04-2024 13:00)